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Asthma in Seniors
Asthma is
sometimes thought of as a “childhood disease,” but it is often
diagnosed as a new condition in older people. For other people, it
may be a continuing problem from younger years. In Michigan,
asthma affects nearly 10% of adults and an estimated 6% of
residents aged 65 and older.
Diagnosing Asthma in
Older People
The
differential diagnosis of episodic chest symptoms in the elderly
expands as cardiovascular disease and other forms of chronic lung
disease become more prevalent. It is important not to misdiagnose
asthma as chronic obstructive pulmonary disease (COPD) because
asthma has a different natural history and a better prognosis with
treatment.
A
person may have asthma if they:
- Present
with episodic wheeze, chest tightness, shortness of breath, or
cough
- Have
recurrent coughing or wheezing episodes as the only symptom
- Have
asthma symptoms that vary throughout the day
- Have
symptoms that worsen
at night, while exercising, or in the presence of airborne
allergens or irritants
- Present
with allergic rhinitis or atopic dermatitis
- Have
relatives with asthma, allergy, sinusitis, or rhinitis
- Have
a physical exam which reveals:
Hyperextension
of the thorax
Wheezing, or prolonged or forced exhalation
Nasal secretions, sinusitis, rhinitis, or nasal polyps
Atopic dermatitis or eczema, or allergic skin problems
Remember,
the absence of symptoms at the time of a physical exam does not
exclude an asthma diagnosis
To
establish an asthma diagnosis:
- Perform
an asthma-specific medical history and physical exam. Be sure
to review all medications the patient is taking. Beta blockers
are known to induce bronchospasm as a side effect.
- Document
by spirometry that airflow obstruction exists and is partially
reversible, i.e.:
FEV1
is < 80% of the predicted limit
FEV1/FVC
is < 75% the lower limit of normal (this ratio decreases
as people age)
FEV1
increases > 12% and at least 200mL after use of a short-acting
inhaled beta2- agonist (i.e., albuterol)
Older
adults may need to use oral steroids for 2-3 weeks before taking
the spirometry test to measure the degree of reversibility
achieved. Chronic bronchitis and emphysema may coexist with asthma
in adults.
Exclude
alternative diagnoses (e.g., vocal cord dysfunction, vascular
rings, foreign bodies, other pulmonary diseases), using additional
tests if necessary.
Normal
spirometry does not exclude the diagnosis of asthma.
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Additional
tests may be required when the patient presents with:
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Appropriate
tests may be:
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Asthma
symptoms but spirometry is normal
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Other factors
contributing to asthma
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- Nasal
exam
- GE
reflux testing
- Allergy
testing
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Infection
(i.e., sinusitis), large airway lesion, heart disease or
foreign body
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- Chest
x-ray
- Sinus
studies
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COPD,
restrictive defect, or central airway obstruction
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- Additional
PFT’s, such as static
lung volumes, exercise testing
diffusing
capacity test
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Distinguishing
Asthma from COPD
| Characteristic |
Asthma |
COPD |
| History |
| Episodic
wheeze |
Common |
Less
common; may occur with exacerbations |
| Nocturnal
dyspnea or Cough |
Common |
Not
common |
| Cough
with phlegm |
Present
more than 40 percent of
cases; common in those who smoke |
Characteristic
of chronic
bronchitis |
Other
allergic symptoms
(rhinitis, conjunctivitis) |
Frequent
|
Infrequent |
| Smoking
history |
Less
common |
Almost
always associated |
| Past
history of asthma |
Common |
Uncommon |
| Family
history of allergy |
Frequent |
Less
frequent |
| Physical
Examination |
| Wheeze |
Common |
Common
after forced expiration or cough |
| Laboratory
Findings |
| Pulmonary
function |
Similar
to COPD |
Similar
to asthma |
| Chest
x-ray |
Often
normal; may show hyperinflation |
¯vessels,
focal hyperaeration (emphysema)
markings
(chronic bronchitis) |
| Eosinophilia |
More
common |
Less
common |
| Positive
skin tests |
More
common |
Less
common |
| Total
serum IgE |
Usually
elevated |
Elevation
less common |
| Response
to Therapy |
| FEV
1
response
to beta 2
-agonist |
FEV
1
with
symptom relief |
Little/no
change in FEV 1
with
poor symptom relief |
Treating Asthma in Seniors
The
goals of asthma treatment are to:
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Prevent chronic asthma symptoms and asthma attacks
during the day and night
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Maintain normal activity levels, including exercise
and other physical activities.
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Have normal or near-normal lung function.
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Be satisfied with the asthma care received.
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Have no or the least side effects while getting the
best medications.
Treating
asthma in the elderly is complicated due to interactions among
effects of aging, asthma and coexisting conditions.
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Normal aging-associated changes in lung structure are
likely to exaggerate asthma symptoms. These changes sometimes make
it difficult to distinguish clearly between asthma and COPD,
especially in patients who have smoked.
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Patients with COPD often have a reversible component to
their condition, and asthma medications may relieve some symptoms
and improve the patient’s quality of life.
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Elderly patients may have a decreased response to influenza
immunization as well as to pneumococcal vaccine and tetanus toxoid.
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Patient education and asthma management plans for elderly
patients should take into consideration possible decreased ability
to handle multiple complex stimuli, memory problems, loss of
coordination and muscle strength that make it difficult to use
metered-dose inhalers, hearing and visual difficulties, sleep
disturbances that may impair cognitive function, and depression.
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Adverse asthma reactions from medications related to
polypharmacy are greater in the elderly. It is important to ask
what other medications the elderly patient with asthma is taking.
Particularly hazardous are beta-adrenergic blocking agents (even
ophthalmic preparations) and, in some patients, non-steroidal
anti-inflammatory drugs and antidepressants.
Non-asthma
Medications with Increased Potential for Adverse Effects in the
Elderly Patient with Asthma
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Medication
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Comorbid
Conditions For Which Drug is Prescribed
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Adverse
Effect
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Comment
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Beta-adrenergic
blocking
agent
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Hypertension
Heart Disease
Tremor
Glaucoma
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Worsening
Asthma
-bronchospasm
-Decreased
response to bronchodilator
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Avoid
where possible; when must be used, use a highly beta-selective
drug
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Nonsteroidal
anti-
inflammatory drugs
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Arthritis
Musculoskeletal
diseases
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Worsening
asthma
• bronchospasm
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Not
all elderly with asthma have nontolerance of
NSAIDs,
but are best avoided if possible
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Non-potassium-
sparing diuretics
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Hypertension
Congestive heart failure
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Worsening
cardiac function/ dysrhythmias due to
hypokalemia
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Additive
effect with antiasthma medications that
also produce potassium loss
(steroids,
beta-agonist); elderly
also more likely to be receiving drugs (e.g., digitalis) where
hypokalemia is of increased concern
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Certain
nonsedating
antihistamines (terfenadine and astemizole)
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Allergic
rhinitis
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Worsening
cardiac function/ ventricular arrythmias due to prolonged QT C
interval
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Cholinergic
agents
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Urinary
retention
Glaucoma
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Bronchospasm
Bronchorrhea
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Also
note that some over- the-counter asthma medications contain
ephedrine, which could aggravate urinary retention, glaucoma
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ACE
inhibitors
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Heart
failure
Hypertension
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Increased
incidence of cough
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Management
of Asthma in Older People
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All
patients need to have regular visits scheduled for their
asthma. Older people need to have a written Asthma Action Plan
that tells them exactly what to do to prevent and treat asthma
symptoms. The plan should be in large print, if necessary, and
reviewed at each office visit.
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Elderly
patients may need assistance in order to keep their asthma
under control. They may have difficulty with transportation,
prescription costs or emotional stress. To help them find
resources that can assist them, click on their county of
residence at "Local Info" on the
home page.
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Desired
therapeutic and clinical outcomes may be more difficult to
achieve in elderly patients with asthma. Normal lung function
may either be unattainable or be attainable only with
potentially dangerous, high pharmacologic doses. It is
important, therefore, to set realistic goals for therapy.
Treatment goals may need to be modified to maintain a
desirable quality of life.
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Because
compliance with multiple therapies – for both asthma and
coexisting diseases and conditions – may be difficult,
elderly patients often need special education and training in
using asthma medications and devices.
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The
potential for drug interactions is greater in elderly patients
with asthma because these patients are likely to be on
multiple medications for other conditions, particularly heart
disease.
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Beta2-agonists
and theophylline use should be monitored carefully because
they can cause tachyarrhythmias and aggravate ischemic heart
disease.
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If
theophylline is used, it should be used with caution,
especially in patients with congestive heart failure.
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Systemic
corticosteriods may aggravate congestive heart failure and
lower serum potassium with potentially adverse cardiac
effects.
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Corticosteroids
in high doses may reduce bone mineral content and may
accelerate development of osteoporosis.
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Peak expiratory flow (PEF) monitoring can contribute significantly
to management. It may also help distinguish asthma symptoms
from symptoms of coexisting heart and lung diseases. However,
the usefulness of PEF monitoring may be limited by age-related
factors that compromise the effort and perceptual and motor
skills required for accurate measurements. Assistance from a
caretaker may be useful.
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Avoidance
of environmental triggers, including tobacco smoke and other
airborne irritants to which the patient is sensitive, is
useful for many elderly patients with asthma.
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It
is important that physicians have a regular follow-up visit
with their patients with asthma. This should be done at least
yearly. The following chart provides the basic elements of a
follow-up visit for asthma with a doctor or asthma counselor.
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A
critical element to managing asthma is education:
1.
Assess the needs of your patient
2.
Set mutually-developed objectives
3.
Try to work out any barriers that stand in the
patient’s way
4.
Create a relaxed, learner-friendly environment
5.
Try different styles of delivery of the educational
material
6.
Assess how well the patient is learning/understanding
the material
7. Refer
to formal asthma education programs in the community
Click here to learn when to
refer patients to an asthma specialist.
Basic
Elements of a Follow-up Office Visit for Asthma
with a Doctor or Asthma Counselor
ELEMENTS
OF A FOLLOW-UP OFFICE VISIT FOR ASTHMA
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The clinician should ask the patient if he or she has experienced
a change in symptoms:
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Nocturnal or early morning awakening with wheezing and
cough
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Shortness of breath
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Cough or phlegm
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Acute episodes of shortness of breath or wheezing
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The clinician should ask the patient if he or she has experienced
a change in exercise tolerance or inability to perform at the
usual level of exertion.
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The clinician should ask the patient about medications taken,
including:
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All prescribed and over-the-counter medications and
“health food” preparations
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Asthma medications and those for other problems
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Dosage and frequency
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Any increase or change in drug use, especially b2-agonists.
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The clinician should note physical findings, especially:
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Change in ventilatory pattern at rest (accessory muscle
use, forced expiration)
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Change in ventilatory pattern with activity
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Ability to speak in full sentences
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Signs of airflow obstruction (expiratory slowing, wheeze,
poor aeration)
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Signs and symptoms of poor oxygenation (tachycardia,
cyanosis)
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Signs of heart failure (edema, gallop rhythm, neck vein
distension).
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Perform spirometry. The clinician should review PEF home
monitoring records, if the patient uses PEF at home, and provide
feedback about the observations. PEF should only be used with
patients with moderate to
severe asthma.
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The clinician should observe the patient’s metered-dose inhaler
and other delivery device techniques (discus, turbohaler, etc.)
and provide appropriate feedback.
•
The clinician should review the patient’s Asthma Management
Plan.
Adapted
from Considerations for Diagnosing and Managing Asthma in the
Elderly, publication no. 96-3662 from the National Institutes of
Health, February 1996, National Heart, Lung and Blood Institute
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